Dr Christine Mummery
Professor of Developmental Biology
Email:
Website:www.niob.knaw.nl/researchpages/mummery/index.html
Christine Mummery studied Physics at the University of Nottingham, UK followed by a PhD in Biophysics at Guy's Hospital Medical School, London. She moved to the Hubrecht Laboratory in the Netherlands as a postdoc to study the differentiation of neuroblastoma cells and regulation of the cell cycle. In 1981 she introduced mouse embryonal carcinoma cells into the laboratory and 3 years later human embryonal carcinoma cells. This was largely in collaboration with Drs C. Graham, J. Heath and M. Pera in Oxford. In 1985 derived mES cell lines with Dr C. Stewart, then at the EMBL in Heidelberg, and introduced that technology to the Hubrecht Laboratory. These cells were used for the studying control of growth and differentiation in early development. In November 2000, collaboration with Dr M. Pera and A.Trounson in Melbourne was re-initiated to study human embryonic stem cells, which they had as second in the world derived successfully. Their hES cell lines were introduced into the Netherlands at the end of that year to study mesoderm differentiation. First results on cardiomycoyte differentiation of hES cells were published recently (Mummery et al, 2003). The Hubrecht Laboratory was closely involved in advising on formulation of the law to derive new lines from embryos (the "Embryowet"). The law permitting human embryo use for this purpose was implemented in September 2002. Ethical approval to derive new lines under this law is pending. Current studies include the role of transforming growth factors in vasculogenesis, development of the heart and cardiovascular disease. In April 2002, Christine Mummery was appointed as ICIN professor of developmental biology of the heart at the University of Utrecht Medical Centre.
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